An Example of a Complex Table

I was sent to make the table below acessible. I was instructed to keep the questions (1.a and 1.b) within the table, so parts of it may be a little verbose. Feedback or questions can be left on the accompanying blog post.

Table A. Summary of findings on treatment of adult depression with strength of evidence
Key question, disorder, and outcome of interest Strength of Evidence 1 Findings
Key Question 1a. Comparative efficacy and effectiveness of second-generation antidepressants
Major Depressive Disorders
Comparative efficacy Moderate

Results from direct and indirect comparisons indicate that no substantial differences in efficacy exist among second-generation antidepressants.

Comparative effectiveness Moderate

Direct evidence from 1 good and 2 fair effectiveness studies and indirect evidence from efficacy trials indicate that no substantial differences in effectiveness exist among second-generation antidepressants.

Quality of life Moderate

Consistent results from 18 studies, most of fair quality, indicate that the efficacy of second-generation antidepressants with respect to quality of life does not differ among drugs.

Onset of action Moderate

Consistent results from 7 fair trials suggest that mirtazapine has a significantly faster onset of action than citalopram, fluoxetine, paroxetine, and sertraline. Whether this difference can be extrapolated to other second-generation antidepressants is unclear. Most other trials do not indicate a faster onset of action of 1 second-generation antidepressant compared with another.

Dysthymia
Comparative efficacy Low

No head-to head evidence exists. Findings from 5 placebo-controlled trials were insufficient to draw conclusions about comparative efficacy.

Comparative effectiveness Low

One fair effectiveness study provides mixed evidence about paroxetine vs. placebo; patients older than 60 showed greater improvement on paroxetine; those younger than 50 did not show any difference.

Quality of life No evidence  
Onset of action No evidence  
Subsyndromal depression
Comparative efficacy Low

One nonrandomized, open-label trial did not detect any difference between citalopram and sertraline. Findings from 2 placebo-controlled trials were insufficient to draw conclusions.

Comparative effectiveness No evidence  
Quality of life No evidence  
Onset of action No evidence  
Key Question 1b: Greater efficacy and effectiveness with previously effective medications
Major depressive disorder No evidence  
Dysthymia No evidence  
Subsyndromal depression No evidence  
© Ryan E. Benson 2006 - 2018
Updated on: 06/14/2011 09:17:33 - Chat with Ryan